RAPID: Resource of Primary Immunodeficiency Diseases

Last updated on May 20, 2013

CFH

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Primary Information

MGI:88385

ENSMUSG00000026365

Gene Symbol

Cfh

Protein Name

Complement factor h

Affected Anatomical Systems

Homeostasis/metabolism

Immune system

Life span-post-weaning/aging

Normal

Renal/urinary system

Allele Details
Allele ID	Allele Symbol	Allele Type	Allele Name	PubMed Id
MGI:2384179	Cfh^tm1Mbo	Targeted (knock-out)	targeted mutation 1, Marina Botto	12091909

Phenotypic Details
Phenotypes	Allelic Composition	Genetic Background	PubMed Id
Premature death	Cfh^tm1Mbo/Cfh^tm1Mbo	involves: 129/Sv * C57BL/6	12091909
Abnormal kidney vasculature morphology	Cfh^tm1Mbo/Cfh^tm1Mbo	involves: 129/Sv * C57BL/6	12091909
Glomerulonephritis	Cfh^tm1Mbo/Cfh^tm1Mbo	involves: 129/Sv * C57BL/6	12091909
Hematuria	Cfh^tm1Mbo/Cfh^tm1Mbo	involves: 129/Sv * C57BL/6	12091909
Proteinuria	Cfh^tm1Mbo/Cfh^tm1Mbo	involves: 129/Sv * C57BL/6	12091909
Abnormal renal glomerulus morphology	Cfh^tm1Mbo/Cfh^tm1Mbo	involves: 129/Sv * C57BL/6	12091909
Abnormal mesangial cell	Cfh^tm1Mbo/Cfh^tm1Mbo	involves: 129/Sv * C57BL/6	12091909
Abnormal circulating protein level	Cfh^tm1Mbo/Cfh^tm1Mbo	involves: 129/Sv * C57BL/6	12091909
Albuminuria	Cfh^tm1Mbo/Cfh^tm1Mbo	involves: 129/Sv * C57BL/6	12091909
Increased susceptibility to type iii hypersensitivity reaction	Cfh^tm1Mbo/Cfh^tm1Mbo	involves: 129/Sv * C57BL/6	12091909
Glomerulonephritis	Cfh^tm1Mbo/Cfh^tm1Mbo	involves: 129/Sv	18202746
Abnormal renal glomerulus morphology	Cfh^tm1Mbo/Cfh^tm1Mbo	involves: 129/Sv	18202746
Abnormal circulating protein level	Cfh^tm1Mbo/Cfh^tm1Mbo	involves: 129/Sv	18202746
Abnormal circulating protein level	Cfh^tm1Mbo/Cfh⁺	involves: 129/Sv * C57BL/6	12091909

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