What is RAPID?
Resource of Asian Primary Immunodeficiency Disease (RAPID) is a freely accessible, dynamic and integrated database on primary immunodeficiency diseases. It hosts information on the sequence variations and expression at the mRNA and protein levels of all genes reported from Primary immunodeficient patients along with protein-protein interaction networks, expression profiles and mouse studies from other available resources.
Why do you develop RAPID?
To build informational platform to access information on primary immune diseases and this is also a part of our actions to initiate a network of PID research in Asia. In RAPID, Asian refers to this earnest attempt to achieve our mission with global perspectives on PID.
Who are the users of RAPID?
The main users of RAPID are clinicians, researchers and biomedical investigators.
How is it different from other PID database(s)/resource(s)?
This is the first of its kind to have detailed and user-friendly information regarding genes and proteins involved in PID with mutation data, protein-protein interaction networks and microarray gene expression profiles in various cells of immune and hematopoietic systems.
What are the criteria for including the mutation variation?
The main criteria are mutation analyses that are performed in patients with the occurrence of set of PID clinical presentations. Carriers and asymptomatic individuals are not included for the annotation.
Does this resource contain unpublished data?
This resource does not contain any unpublished data.
Do you have reference sequences for mutation entries?
Yes, mutation data have been mapped to available reference genomic; mRNA and protein sequences, as given in Entrez Gene at NCBI.
Do you follow any standardization for representing mutation data?
Yes, we do follow nomenclature and recommendations of sequence variants as proposed by Human Genome Variation Society (HGVS).
Does RAPID contain clinical information?
No clinical information has been included so far.
Can I get genotype-phenotype correlation?
In RAPID, allele based mouse phenotypes have been mapped to human orthologous primary immunodeficiency disease genes from Mouse Genome Informatics (MGI). Thus, this data would serve as a connecting link between the genotype and the phenotype.
How does browse/query interface arranged to access information?
User can query this resource with various options such as gene symbol, protein name, mouse phenotypes, synonyms, chromosome number, PID category, accession number of other gene databases with user-friendly autocomplete option provided wherever possible and also browse by PID genes, disease names, mutation type, mutation effect and inheritance.
How do I get other relevant information on the respective genes and diseases?
Relevant External links such as Entrez, OMIM, IDR fact file, etc are provided on the Primary information page of each gene. In case of OMIM both the gene as well as phenotype entry links are given.
To whom should I contact for sending feedback/comments about this resource?
Please send your feedback or comments about RAPID to firstname.lastname@example.org
Who funded this project?
RAPID is constructed under the support by Special Coordination Funds for Promoting Science and Technology (The Asia S&T Strategic Cooperation Promotion Program by The Japanese Ministry of Education, Culture, Sports, Science and Technology; MEXT)