| Factor H deficiency |
Progressive renal insufficiency; Membranoproliferative glomerulonephritis type II; Thickening of the glomerular basement membrane on renal biopsy; Deposition of complement component C3 in glomerular basement membrane; Hematuria; Continuous activation of the alternative complement pathway; Hypocomplementemia; Depletion of components of the alternative complement pathway; Increased susceptibility to certain bacterial infections, especially neisseria meningitidis; Decreased serum complement factor H; Normal levels of complement factor H, but impaired function; Hypocomplementemia; IgA nephropathy |
Complement Deficiencies |
Autosomal dominant; Autosomal recessive |
